Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells

نویسندگان

  • Allison Suarez
  • Tasuku Ueno
  • Robert Huebner
  • J. Michael McCaffery
  • Takanari Inoue
چکیده

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2014